Thunder Data Portal


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Interesting genes

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This data portal is in support of the manuscript: "Memory T cell mRNA splicing is reprogrammed by heterogeneous nuclear ribonucleoprotein hnRNPLL" (Wu et al., Immunity, in press), which involves collaboration between the Goodnow Lab in the Immunogenomics Group at Australia National University and the Aderem and Shmulevich labs at the Institute for Systems Biology. This collaboration is part of the Systems Approach to Immunology, a research program formed to study the mechanisms by which the immune system responds to infectious disease by inciting innate inflammatory reactions and instructing adaptive immune responses, and supported by the National Institute of Allergy and Infectious Disease (NIAID), a division of the National Institutes of Health.

The purpose of this data portal is to give researchers easy access to the rich gene expression data published in Wu et al. manuscript, in particular to allow them to directly search through analyzed data and determine whether their genes of interest are are differentially expressed or differentially spliced in Thunder (Hnrnpll) mutant vs. wild type or memory (CD44+) vs. naive(CD44lo) T cells. In addition, groups of alternatively spliced genes identified in the manuscript, as well as lists of genes that are differentially expressed between the conditions, are easily accessible through the portal through the interesting genes link.