Systems Approach to Immunology was a collaborative research program formed to study the mechanisms by which the immune system responds to infectious disease by inciting innate inflammatory reactions and instructing adaptive immune responses. This multidisciplinary international consortium included researchers from the Scripps Research Institute, the Institute for Systems Biology, the Australian National University, and Stanford University. The program was made possible by funding from the National Institute of Allergy and Infectious Diseases (NIAID), a division of the National Institutes of Health, from 2007-2012.
The consortium was comprised of seven Cores with the aim of developing a detailed model of immune responses to both bacterial and viral pathogens. This web site is designed for the dissemination of our work to the scientific community. Under the tabs at the top of this page, you will find a description of the work performed by each Core, as well as links to data sets and to protocols that were used to generate these datasets. Data generated by this consortium are freely available to the scientific community. These data are available in raw form and in processed forms so that they may be explored without need for specialized training in computational analysis or bioinformatics.
The next iteration of our program continues at SystemsImmunity.org. Again funded by NIH/NIAID (grant U19 AI100627), Systems Immunity focuses on dissecting the immune response to infectious disease through the application of "Systems-Guided Forward Genetics." By combining traditional forward genetics and systems biology methodologies, we aim to advance our understanding of immune responses by accelerating the identification of critical regulators of immunity.